The following research study summaries were retrieved from a Medline search using the keywords “erectile dysfunction shockwave therapy”.  I have summarized the study abstracts.

Searches were limited to citations providing abstracts, published within the last 5 years and on human subjects.

 

I have highlighted parts of each citation for emphasis.  Copy and paste the study title into your web browser to view the entire study abstract.


 

J Sex Med. 2017 Jul;14(7):891-897. doi: 10.1016/j.jsxm.2017.05.012.

 

Low-Intensity Shockwave Therapy Improves Hemodynamic Parameters in Patients With
Vasculogenic Erectile Dysfunction: A Triplex Ultrasonography-Based
Sham-Controlled Trial.

Kalyvianakis D(1), Hatzichristou D(2).

Author information:
(1)Center for Sexual and Reproductive Health, Aristotle University of
Thessaloniki Greece, Thessaloniki, Greece.
(2)Center for Sexual and Reproductive Health, Aristotle University of
Thessaloniki Greece, Thessaloniki, Greece. Electronic address:
hatzichr@med.auth.gr.

CLINICAL IMPLICATIONS: Such results offer objective and subjective documentation
of the value of this novel treatment modality for men with vasculogenic ED.

CONCLUSION: The present study confirms the beneficial effect of LI-ESWT on penile
hemodynamics and the beneficial effect of this treatment up to 12 months.


2. J Sex Med. 2017 Apr;14(4):493-501. doi: 10.1016/j.jsxm.2017.02.004. Epub 2017 Mar 1.

In Situ Activation of Penile Progenitor Cells With Low-Intensity Extracorporeal
Shockwave Therapy.

Lin G(1), Reed-Maldonado AB(1), Wang B(2), Lee YC(3), Zhou J(4), Lu Z(5), Wang
G(1), Banie L(1), Lue TF(6).

Author information:
(1)Knuppe Molecular Urology Laboratory, Department of Urology, School of
Medicine, University of California-San Francisco, San Francisco, CA, USA.
(2)Knuppe Molecular Urology Laboratory, Department of Urology, School of
Medicine, University of California-San Francisco, San Francisco, CA, USA;
Department of Urology, The Second Hospital, Zhejiang University, Zhejiang, China.
(3)Knuppe Molecular Urology Laboratory, Department of Urology, School of
Medicine, University of California-San Francisco, San Francisco, CA, USA;
Department of Urology, Kaohsiung Medical University Hospital, and Department of
Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University,
Kaohsiung, Taiwan.
(4)Knuppe Molecular Urology Laboratory, Department of Urology, School of
Medicine, University of California-San Francisco, San Francisco, CA, USA;
Department of Urology, The Third XiangYa Hospital, Central South University,
Changsha, China.
(5)Knuppe Molecular Urology Laboratory, Department of Urology, School of
Medicine, University of California-San Francisco, San Francisco, CA, USA;
Department of Urology, The First Hospital of Jilin University, Changchun, China.
(6)Knuppe Molecular Urology Laboratory, Department of Urology, School of
Medicine, University of California-San Francisco, San Francisco, CA, USA.
Electronic address: Tom.Lue@ucsf.edu.

CONCLUSION: Li-ESWT activation of local penile progenitor cells might be one of
the mechanisms that contribute to the beneficial effects of shockwave treatment
for erectile dysfunction, which represents a non-invasive alternative to
exogenous stem cell therapy.


J Sex Med. 2017 Jan;14(1):27-35. doi: 10.1016/j.jsxm.2016.11.001. Epub 2016 Dec13.

Effects of Low-Intensity Extracorporeal Shockwave Therapy on Erectile
Dysfunction: A Systematic Review and Meta-Analysis.

Clavijo RI(1), Kohn TP(2), Kohn JR(2), Ramasamy R(3).

Author information:
(1)Department of Urology, University of California, Los Angeles, CA, USA.
(2)Baylor College of Medicine, Houston, TX, USA.
(3)Department of Urology, Miller School of Medicine, University of Miami, Miami,
FL, USA. Electronic address: ramasamy@miami.edu.

INTRODUCTION: Low-intensity extracorporeal shock wave therapy (Li-ESWT) has been
proposed as an effective non-invasive treatment option for erectile dysfunction
(ED).
AIM: To use systematic review and meta-analysis to assess the efficacy of Li-ESWT
by comparing change in erectile function as assessed by the erectile function
domain of the International Index of Erectile Function (IIEF-EF) in men
undergoing Li-ESWT vs sham therapy for the treatment of ED.

CONCLUSION: In this meta-analysis of seven randomized controlled trials,
treatment of ED with Li-ESWT resulted in a significant increase in IIEF-EF
scores.


Zhonghua Nan Ke Xue. 2016 Jul;22(7):654-658.

[Low-intensity extracorporeal shockwave therapy for erectile dysfunction: An
update].

[Article in Chinese; Abstract available in Chinese from the publisher]

Zou ZJ(1), Lu YP(1).

Author information:
(1)Department of Urology, West China Hospital, Sichuan University, Chengdu,
Sichuan 610041, China.

Low-intensity extracorporeal shockwave therapy (LI-ESWT) is a novel treatment for
erectile dysfunction (ED). With the property of angiogenesis, LI-ESWT acts on
vasculogenic ED by improving penile hemodynamics and endothelial function.
LI-ESWT is proved to be safe and effective in the treatment of vasculogenic ED in
various prospective clinical studies, including randomized, double-blind, and
sham-controlled trails. With more multi-centered larger-sample randomized
controlled trials, LI-ESWT will play a valuable role in the treatment of ED.


Scand J Urol. 2016;50(2):123-7. doi: 10.3109/21681805.2015.1100675. Epub 2015 Oct
23.

Low-intensity extracorporeal shockwave therapy in the treatment of
postprostatectomy erectile dysfunction: a pilot study.

Frey A(1), Sønksen J(1), Fode M(1).

Author information:
(1)a Department of Urology , Herlev University Hospital , Copenhagen , Denmark.

OBJECTIVE: The objective was to investigate the effect and feasibility of
low-intensity extracorporeal shockwave therapy (LI-ESWT) as a treatment for
erectile dysfunction (ED) after bilateral nerve-sparing radical prostatectomy
(RP).
CONCLUSIONS: LI-ESWT may improve erectile function after bilateral nerve-sparing
RP. Based on these results, further studies in patients with ED after
nerve-sparing RP are justified.


BJU Int. 2015 Apr;115 Suppl 5:46-9. doi: 10.1111/bju.13035.

Evaluation of clinical efficacy, safety and patient satisfaction rate after
low-intensity extracorporeal shockwave therapy for the treatment of male erectile
dysfunction: an Australian first open-label single-arm prospective clinical
trial.

Chung E(1), Cartmill R.

Author information:
(1)Department of Urology, Princess Alexandra Hospital, University of Queensland,
Brisbane, Qld, Australia; St. Andrew’s Pelvic Medicine Centre, St Andrew’s War
Memorial Hospital, Brisbane, Qld, Australia.

OBJECTIVE: To evaluate the efficacy, safety and patient satisfaction rate with
low-intensity extracorporeal shockwave therapy (LiESWT) in Australian men with
erectile dysfunction (ED), as LiESWT induces neovascularisation and potentially
enhances penile perfusion and improves erectile function.

CONCLUSION: LiESWT appears to improve erectile function, is safe and potential
plays an important role in penile rehabilitation in men whom failed medical
therapy.


Can J Urol. 2015 Feb;22(1):7614-22.

Low intensity extracorporeal shockwave therapy for erectile dysfunction: a study
in an Indian population.

Srini VS(1), Reddy RK, Shultz T, Denes B.

Author information:
(1)Ankur Healthcare Private Limited, Bangalore, India; Medispec Ltd.,
Gaithersburg, Maryland, USA; Redwood City, California, USA.

INTRODUCTION: Erectile dysfunction (ED) has been shown to be associated with a
number of physical conditions and affects not only physical but also psychosocial
health. Currently oral, on-demand phosphodiesterase type 5 inhibitors (PDE5i) are
preferred first line treatment. Though effective, these drugs have limitations
and are associated with significant non-compliance, side effects and do not
reverse the underlying pathology. Non-invasive low intensity shockwave therapy
(LISWT) has been shown to significantly improve erectile function in men
previously PDE5i dependent. We describe our experience and results with this
therapy in an Indian population of men with ED. This study assessed the efficacy
of low intensity extracorporeal shockwave therapy (LI-ESWT) on Indian men with
organic ED who had previously responded to PDE5i.
CONCLUSIONS: In this double-blind, placebo-controlled study, LI-ESWT demonstrated
a positive long term clinical effect with improvement in erectile function of
Indian men with vasculogenic ED who were prior responders to PDE5i therapy. The
efficacy and tolerability of this treatment, coupled with its long term benefits
and rehabilitative characteristics, make it an attractive new therapeutic option
for men with vasculogenic erectile dysfunction.


Int J Impot Res. 2015 May-Jun;27(3):108-12. doi: 10.1038/ijir.2014.41. Epub 2014
Dec 4.

Initial experience with linear focused shockwave treatment for erectile
dysfunction: a 6-month follow-up pilot study.

Reisman Y(1), Hind A(2), Varaneckas A(3), Motil I(4).

Author information:
(1)Men’s Health Clinic, Amstelland Hospital, Amsterdam, The Netherlands.
(2)Urology and Andrology Center, Red Crescent Hospital (RCH), Ramallah,
Palestine.
(3)Amber Clinic, Klaipėda, Lithuania.
(4)Urologickaambulance.cz, Brno, Czech Republic.

Low-intensity shockwaves (LISW) are known to produce revascularization and have
been in evaluation and in use to treat erectile dysfunction (ED). The present
single-arm pilot study is aimed to assess the safety and efficacy of a dedicated
shockwave device (Renova) on vasculogenic ED patients. Fifty-eight patients with
mild to severe ED were treated by LISW and their erectile function was evaluated
by the International Index of Erectile Function-Erectile Function Domain
(IIEF-EF), Sexual Encounter Profile and Global Assessment Questions
questionnaires, at baseline and at 1, 3 and 6 months post treatment. The average
IIEF-EF increased significantly from 14.78 at baseline to 21.93 at 3 months post
treatment and stabilized at 22.26 at 6 months post treatment. Out of 58 patients,
47 (81%) had a successful treatment. No adverse events were reported during the
treatment and the follow-up duration. In conclusion, it suggests that the
performance of LISW could add a new advanced treatment for ED.


Zhonghua Nan Ke Xue. 2014 Sep;20(9):846-9.

[Extracorporeal shockwave therapy for erectile dysfunction and Peyronie’s
disease].

[Article in Chinese]

Zhu JY, Jiang R.

Penile vascular endothelial damage, vasomotor dysfunction, and blood flow
deficiency are the major causes of erectile dysfunction (ED). Current management
of ED mostly depends on selective phosphodiesterase type 5- (PDE5) inhibitors,
which fail for some ED patients. For Peyronie’s disease-induced ED, surgical and
physical therapies are used in addition to PDE5I medication, but frequently it is
difficult to achieve satisfactory results. Recent studies show that the
low-intensity extracorporeal shockwave therapy can promote angiogenesis and
improve blood flow to the penis, which promises to be a novel effective therapy
for ED and Peyronie’s disease.


Int J Urol. 2014 Oct;21(10):1041-5. doi: 10.1111/iju.12506. Epub 2014 Jun 17.

Extracorporeal shockwave therapy in the treatment of erectile dysfunction: a
prospective, randomized, double-blinded, placebo controlled study.

Yee CH(1), Chan ES, Hou SS, Ng CF.

Author information:
(1)Division of Urology, Department of Surgery, Prince of Wales Hospital, The
Chinese University of Hong Kong, Hong Kong, China.

OBJECTIVES: To investigate the role of low-intensity extracorporeal shockwave
therapy in the treatment of erectile dysfunction.

CONCLUSION: The present trial shows the tolerability and clinical efficacy of
low-intensity extracorporeal shockwave therapy in a subgroup of patients with
erectile dysfunction.